4-Methoxybenzoyl Chloride

4-Methoxybenzoyl Chloride is an aromatic acyl chloride used as a reactive intermediate in organic and specialty chemical synthesis. It contains a para-methoxy-substituted benzoyl group and an acid chloride functional group for introducing the 4-methoxybenzoyl structure into downstream compounds.

The product is identified by CAS No. 100-07-2, molecular formula C₈H₇ClO₂, and molecular weight 170.59 g/mol. Its defined molecular structure makes it suitable for synthesis routes requiring a specific aromatic acylating intermediate.

Defined acylating group
The acid chloride group provides a direct reaction site for transferring the 4-methoxybenzoyl unit to suitable organic substrates.

Para-methoxy substitution
The para-methoxy arrangement provides a defined aromatic structure for synthesis routes requiring this specific substitution pattern.

Temperature-sensitive physical state
With a melting point near room temperature, the material may change physical state during handling. Temperature control should be considered when defining storage and transfer procedures.

Amide synthesis
Reaction with amines provides a route to 4-methoxybenzamide derivatives and related intermediates.

Ester synthesis
Reaction with alcohol-containing substrates can produce corresponding 4-methoxybenzoate structures for further synthetic steps.

Ketone synthesis
The compound can be used as an acylating component in synthetic routes involving aromatic ketones and related carbonyl compounds.

Heterocyclic synthesis
The 4-methoxybenzoyl unit can be incorporated into routes for substituted heterocyclic intermediates where this aromatic group is required.

Assay
The required assay should match the reaction specification and the allowable impurity level of the downstream process.

Moisture control
Acid chlorides react with moisture. Exposure during sampling, storage and process transfer should therefore be controlled.

Physical form
The melting point of approximately 22–23°C should be considered when selecting storage, transfer and dosing conditions.

Identity
Analytical testing should confirm the expected molecular structure and distinguish the material from related aromatic acyl chlorides.

Purity
Assay testing establishes the concentration of the target compound for specification and batch-release control.

Impurities
Defined impurity limits provide a measurable basis for evaluating material suitability for downstream synthesis.

Stoichiometry
The required molar ratio should be established according to the substrate, reaction pathway and target conversion.

Addition rate
Controlled addition can help maintain consistent reaction conditions when the acid chloride is introduced into the process.

Temperature
Reaction and transfer temperatures should account for the material's melting point and the operating requirements of the specific synthesis.

Temperature
Reference product information lists storage at 0–10°C for this material. Actual storage conditions should follow the applicable product specification and SDS.

Moisture protection
The container should provide effective protection from atmospheric moisture throughout storage and transportation.

Inert atmosphere
Published product information recommends storage under inert gas. This condition should be incorporated where required by the applicable handling procedure.

Certificate of Analysis
A batch-specific COA provides analytical results for incoming material verification and specification review.

Product specification
The agreed specification should define assay, impurity limits and relevant physical parameters.

Technical data
CAS number, molecular formula, molecular weight and key physical properties provide the basic identification data required for technical qualification.

Application Fit
4-Methoxybenzoyl Chloride fits synthesis routes requiring a defined 4-methoxybenzoyl acylating unit. The acid chloride functionality supports direct incorporation of this aromatic group into amides, esters, ketones and related intermediates.
Material selection should be based on the required structure, assay, impurity limits, physical handling conditions and downstream reaction requirements.

Specification
Confirm CAS number, required assay, impurity limits and physical form before order confirmation.

Quantity
Define the required quantity and intended production stage so that packaging and handling requirements can be matched to the process.

Documentation
Confirm the required COA, specification and technical documentation before material qualification.

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