The substance with CAS 80-15-9 refers to 2,4-Di-tert-butylphenol. As a reliable supplier of CAS 80-15-9, we are committed to providing comprehensive information about this chemical, including its toxicological data. Understanding the toxicological properties of a substance is crucial for ensuring safety in its handling, storage, and use. In this blog, we will delve into the various aspects of the toxicological data of 2,4-Di-tert-butylphenol.
Physical and Chemical Properties
Before discussing the toxicological data, it is important to have a basic understanding of the physical and chemical properties of 2,4-Di-tert-butylphenol. It is a white to pale yellow crystalline solid with a characteristic odor. The molecular formula is C14H22O, and it has a molecular weight of approximately 206.32 g/mol. It is insoluble in water but soluble in organic solvents such as ethanol, ether, and benzene. These properties play a role in determining its behavior in the environment and its potential to interact with biological systems.
Acute Toxicity
Acute toxicity refers to the adverse effects that occur shortly after exposure to a single dose or a short - term exposure to a substance.
- Oral Toxicity: Studies on animals have shown that the oral LD50 (lethal dose for 50% of the test population) of 2,4 - Di - tert - butylphenol varies depending on the species. For rats, the oral LD50 is in the range of several hundred milligrams per kilogram of body weight. This indicates that ingestion of a relatively large amount of the substance can be fatal. Symptoms of acute oral toxicity may include gastrointestinal distress, central nervous system depression, and respiratory problems.
- Dermal Toxicity: The dermal LD50 of 2,4 - Di - tert - butylphenol is also significant. Skin contact with the substance can cause irritation, redness, and in severe cases, chemical burns. Prolonged or repeated dermal exposure may lead to more serious skin damage and systemic effects if the substance is absorbed through the skin.
- Inhalation Toxicity: Inhalation of 2,4 - Di - tert - butylphenol vapors or dust can cause irritation to the respiratory tract. High - level inhalation exposure may result in coughing, shortness of breath, and in extreme cases, pulmonary edema. The LC50 (lethal concentration for 50% of the test population) for inhalation in animals is a measure of the concentration of the substance in the air that can cause death. However, specific LC50 values may vary depending on the experimental conditions and the species tested.
Chronic Toxicity
Chronic toxicity refers to the long - term adverse effects that occur as a result of repeated or continuous exposure to a substance over an extended period.
- Carcinogenicity: There is limited evidence regarding the carcinogenic potential of 2,4 - Di - tert - butylphenol. Some in vitro studies have shown that it may have certain genotoxic effects, which are related to DNA damage. However, more comprehensive in vivo studies are needed to determine its carcinogenicity in humans. At present, it is not classified as a known human carcinogen by major regulatory agencies, but the potential risk cannot be completely ruled out.
- Mutagenicity: Mutagenicity refers to the ability of a substance to cause mutations in the DNA of cells. In some mutagenicity assays, 2,4 - Di - tert - butylphenol has shown positive results, indicating that it may have the potential to induce genetic changes. These mutations can lead to various health problems, including an increased risk of cancer and genetic disorders.
- Reproductive and Developmental Toxicity: Animal studies have suggested that 2,4 - Di - tert - butylphenol may have adverse effects on reproduction and development. It may affect the fertility of male and female animals, and exposure during pregnancy can lead to developmental abnormalities in the offspring. These effects are likely due to the disruption of hormonal and biochemical processes in the body.
Environmental Toxicity
2,4 - Di - tert - butylphenol can also have an impact on the environment.
- Aquatic Toxicity: It is toxic to aquatic organisms. In water, it can bioaccumulate in the tissues of fish and other aquatic animals. The substance can cause acute and chronic toxicity to fish, invertebrates, and algae. For example, it can affect the growth, reproduction, and survival of these organisms. The EC50 (effective concentration for 50% of the test population) values for aquatic organisms are relatively low, indicating high sensitivity to the substance.
- Soil and Sediment Toxicity: In soil and sediment, 2,4 - Di - tert - butylphenol can persist for a certain period. It can affect soil microorganisms, which play an important role in soil fertility and nutrient cycling. The presence of the substance in soil can also have implications for the growth of plants, as it may interfere with their physiological processes.
Safety Precautions and Handling
Based on the toxicological data, appropriate safety precautions should be taken when handling 2,4 - Di - tert - butylphenol.
- Personal Protective Equipment (PPE): When working with the substance, wear appropriate PPE, such as gloves, goggles, and a lab coat. This can prevent skin contact and eye exposure. If there is a risk of inhalation, use a respirator with appropriate filters.
- Storage and Handling: Store 2,4 - Di - tert - butylphenol in a cool, dry, and well - ventilated area. Keep it away from sources of heat, sparks, and open flames. Follow proper handling procedures to minimize the risk of spills and releases. In case of a spill, clean it up immediately using appropriate absorbent materials and dispose of the waste according to local regulations.
Comparison with Other Related Substances
To put the toxicological data of 2,4 - Di - tert - butylphenol in perspective, it is useful to compare it with other related substances. For example, TBPIN | CAS 13122-18-4 | Tert - butylperoxy - 3,5,5 - trimethylhexanoate, DHBP | CAS 78-63-7 | 2,5 - Dimethyl - 2,5 - di(tert - butylperoxy)hexane, and TBPO | CAS 3006-82-4 | Tert - butylperoxy - 2 - ethylhexanoate are all organic peroxides. While 2,4 - Di - tert - butylphenol is a phenolic compound, these organic peroxides have different chemical structures and toxicological profiles. Organic peroxides are generally more reactive and can pose a greater risk of fire and explosion. However, they also have their own specific toxicological properties, such as potential irritation and toxicity to the respiratory and skin systems.
Conclusion
In conclusion, 2,4 - Di - tert - butylphenol has a range of toxicological properties that need to be carefully considered. Its acute toxicity, chronic toxicity, and environmental toxicity all highlight the importance of proper handling, storage, and use. As a supplier of CAS 80 - 15 - 9, we are committed to providing our customers with high - quality products and comprehensive safety information. If you are interested in purchasing 2,4 - Di - tert - butylphenol or have any questions regarding its use and safety, please feel free to contact us for further discussion. We can work together to ensure that the product is used in a safe and responsible manner.
References
- Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Phenols.
- European Chemicals Agency (ECHA). Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) database for 2,4 - Di - tert - butylphenol.
- Various scientific research papers on the toxicology of 2,4 - Di - tert - butylphenol published in peer - reviewed journals.