2,4-Difluorobenzoyl Chloride

2,4-Difluorobenzoyl Chloride is an aromatic acyl chloride used as an acylating intermediate in organic synthesis. Its structure contains a benzoyl chloride group with fluorine substitution at the 2- and 4-positions, providing a defined fluorinated aromatic building block for downstream synthesis.

The product is identified by CAS No. 72482-64-5, molecular formula C₇H₃ClF₂O, and molecular weight 176.55 g/mol. It is handled as a liquid and is moisture sensitive.

Defined Fluorine Substitution
Fluorine atoms occupy the 2- and 4-positions of the aromatic ring, giving the material a specific substitution pattern for synthesis planning.

Reactive Acyl Chloride
The benzoyl chloride functional group provides an active acylation site for introducing the 2,4-difluorobenzoyl group into downstream compounds.

Identifiable Material Profile
CAS number, molecular formula, molecular weight, purity, and physical properties provide clear reference points for material identification and incoming inspection.

Pharmaceutical Intermediates
The compound is used as an aromatic acylating intermediate in synthetic routes involving fluorinated pharmaceutical intermediates.

Organic Synthesis
The acid chloride group supports acylation reactions with compatible nucleophilic compounds, including amines and alcohols.

Process Development
Its defined molecular structure and analytical profile make it suitable for route development, intermediate preparation, and process chemistry involving 2,4-difluorobenzoyl structures.

Confirm CAS Identity
Confirm CAS 72482-64-5 together with the molecular formula before material approval to distinguish the required compound from other fluorinated benzoyl chlorides.

Set Purity
Define the required assay according to the reaction step and downstream process. Public commercial specifications include ≥98.0% GC.

Review Moisture Sensitivity
Moisture control is an important part of storage and handling because the acid chloride reacts with water.

Moisture Protection
Keep containers tightly closed and minimize exposure to atmospheric moisture during handling.

Storage Conditions
Published storage guidance specifies room-temperature storage, with cool and dark conditions below 15 °C recommended for one commercial grade.

Inert Atmosphere
An inert atmosphere is specified in published product information and can be incorporated into storage procedures where required.

Identity Testing
Confirm chemical identity through the agreed analytical methods, supported by CAS number, molecular formula, and structural data.

Purity Testing
GC assay is a key quality parameter, with 98.0% minimum reported in published commercial specifications.

Batch Records
Batch documentation should record the tested values against the agreed specification, allowing incoming inspection and production records to be matched.

Certificate of Analysis
A batch-specific COA should state the applicable specification and analytical results for the delivered material.

Safety Data Sheet
An SDS should provide the information required for handling, storage, transportation, and site safety review.

Technical Specification
The product specification should define identity, assay, appearance, analytical method, and other agreed release parameters.

Moisture-Protective Packaging
Packaging should maintain container integrity and limit moisture exposure throughout storage and transportation.

Quantity Planning
State the required quantity and intended production stage when requesting pricing and technical confirmation.

Shipment Documents
Confirm the required COA, SDS, specification sheet, packaging details, and destination-specific transport documents before shipment.

For a technical quotation, provide:
● Required purity
● Required quantity
● Intended synthesis or application
● Packaging requirement
● Destination country
● Required documentation
● Internal analytical specification, if applicable
Clear technical requirements allow the material specification, documentation, packaging, and shipment conditions to be confirmed together.

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