4-Bromobenzoyl Chloride

4-Bromobenzoyl Chloride is an aromatic acyl chloride used to introduce a 4-bromobenzoyl group into organic synthesis routes. Its molecular structure combines a para-bromo aromatic ring with a reactive acid chloride group, providing a defined intermediate for acylation and subsequent functionalization.

The product is identified by CAS No. 586-75-4, molecular formula C₇H₄BrClO, and molecular weight 219.46 g/mol. Its reported melting range is approximately 36–42°C, placing the material close to its melting transition during normal handling.

Defined Para-Bromo Structure
The para-bromo substitution provides a specific aromatic structure for synthesis routes requiring a brominated benzoyl intermediate.

Dual Synthetic Functionality
The acid chloride supports acylation, while the aryl bromide can remain available for later chemical transformation when compatible with the selected route.

Chemical Identity
Match the CAS number, molecular formula, molecular weight, and intended substitution pattern with the synthesis specification before qualification.

Purity Requirement
Set the required assay according to the reaction step and downstream impurity tolerance. Public commercial specifications commonly list ≥98.0% by GC, but the applicable product specification should be confirmed for the supplied batch.

Physical Form
The low melting range is relevant to sampling, weighing, and temperature management during storage and processing.

Aromatic Acylation
The acid chloride group enables introduction of the 4-bromobenzoyl moiety into suitable amines, alcohols, and other compatible nucleophiles.

Intermediate Preparation
The compound can serve as an intermediate where the brominated aromatic ring is retained for subsequent synthetic steps.

Pharmaceutical Intermediate Routes
Its defined aromatic substitution and acyl chloride functionality can be incorporated into multi-step routes for pharmaceutical-related intermediates.

Functionalized Aromatic Compounds
The combination of an aryl bromide and acid chloride provides two chemically distinct functional sites for route development.

Moisture Control
Acid chlorides react with water. Dry process conditions and closed handling help preserve the reactive acyl chloride group during storage and use.

Reaction Parameters
Solvent, base, temperature, addition rate, and substrate concentration should be established according to the specific reaction and required conversion.

Downstream Chemistry
The aryl bromide may provide a further reaction site after acylation, depending on the selected synthetic pathway and reaction conditions.

Identity Testing
FTIR or another validated analytical method can confirm the expected chemical identity and functional groups.

Assay Testing
GC provides a practical quantitative method for assessing organic purity and monitoring batch quality.

Physical Check
Appearance and melting range provide additional batch-level checks during incoming inspection and material release. Published specifications report ranges around 36–42°C.

Moisture Protection
Use tightly sealed packaging suitable for moisture-sensitive acid chlorides. Minimize exposure during opening, sampling, and transfer.

Temperature Control
The melting range should be considered when selecting storage and transportation conditions, particularly for longer transit periods.

Batch Documentation
A product specification, SDS, and batch-specific COA are useful for material qualification and incoming quality review.

Temperature
Published commercial specifications list refrigerated storage conditions, including 0–10°C or 2–8°C depending on the specification.

Moisture Protection
Keep containers tightly closed and protect the material from atmospheric moisture.

Inert Atmosphere
Where specified by the applicable handling procedure, storage under an inert atmosphere can further limit moisture exposure.

Required Specification
Include required assay, quantity, packaging format, and analytical documentation when requesting a quotation.

Application Requirements
State the intended synthesis step and any critical analytical limits that affect material qualification.

Shipment Planning
Confirm packaging, transport conditions, documentation, destination, and requested delivery schedule before shipment.

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